1. Cancer modeling thinks big with the pig
    Feb 11, 2019


  1. A Porcine Model of Neurofibromatosis Type 1 That Mimics the Human Disease
    June 21, 2018
  2. H19 Induces Abdominal Aortic Aneurysm Development and Progression
    April 18, 2018
  3. Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR+/- and LDLR-/-) Yucatan Miniature Pigs
    April 18, 2018


  1. Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs
    September 2017
  2. Postnatal Airway Growth in Cystic Fibrosis Piglets
    June 2017
  3. Monocyte Derived Macrophages From CF Pigs Exhibit Increased Inflammatory Responses at Birth
    April 2017


  1. Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus
    October 2016
  2. Lentiviral-Mediated Phenotypic Correction of Cystic Fibrosis Pigs
    September 2016
  3. CFTR Gene Transfer With AAV Improves Early Cystic Fibrosis Pig Phenotypes
    September 2016
  4. Repurposing Tromethamine as Inhaled Therapy to Treat CF Airway Disease
    June 2, 2016
  5. Dystrophin Exon 52-Deleted Pigs as a New Animal Model of Duchenne Muscular Dystrophy: Its Characterization and Potential as a Tool for Developing Exon Skipping Therapy
    May 2016
  6. Novel Large Animal Model of Xanthoma Formation
    March 2016
  7. Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus
    March 2016
  8. A Translational Model for Diet-Related Atherosclerosis: Effect of Statins on Hypercholesterolemia and Atherosclerosis in a Minipig
    February 16, 2016
  9. Supplementary Material for Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung
    February 2016
  10. Electrolyte Transport Properties in Distal Small Airways From Cystic Fibrosis Pigs With Implications for Host Defense
    January 2016


  1. Discovering a Molecular Basis for Airway Smooth Muscle Dysfunction Through Genome Wide Transcriptional Analysis in the CF Pig
    October 2015
  2. Using Newborn CF and Non-CF Pigs to Assess Airway Mucus
    October 2015
  3. Calprotectin Expression is Constitutively Altered in the CF Pig at Birth Prior to the Onset of Neutrophil-Mediated Inflammation
    October 2015
  4. Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans
    October 2015
  5. Lentiviral Vector-Mediated CFTR Gene Transfer to CF Pig Airways Corrects the Anion Transport Defect In Vivo
    May 2015


  1. CFTR Expression Contributes to Fluid Secretion and is Induced By FGF10 in Fetal Pig Lung
    September 2014
  2. Airway Mucus and Early Evidence of Gas Trapping in the CF Pig
    September 2014
  3. Impaired Mucus Detachment Disrupts Mucociliary Transport in Newborn Pigs Lacking CFTR Anion Channels
    September 2014
  4. Development and Translational Imaging of a TP53 Porcine Tumorigenesis Model
    August 8, 2014
  5. Impaired Mucus Detachment Disrupts Mucociliary Transport in a Piglet Model of Cystic Fibrosis
    August 2014
  6. Glycemic Regulation and Insulin Secretion Are Abnormal in Cystic Fibrosis Pigs Despite Sparing of Islet Cell Mass
    August 2014
  7. Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs
    April, 2014
  8. Porcine Nasal Epithelial Cultures for Studies of Cystic Fibrosis Sinusitis.
    April 14, 2014
  9. Abundance of DNase-Susceptible Bacterial DNA from Damaged Cells in the Lungs of Pigs
    January 2014
  10. Assessing Mucociliary Transport of Single Particles in Vivo Shows Variable Speed and Preference for the Ventral Trachea in Newborn Pigs
    January 2014


  1. Early Airway Structural Changes in Cystic Fibrosis Pigs as a Determinant of Particle Distribution and Deposition
    December 2013
  2. A Novel Gene Delivery Method Transduces Porcine Pancreatic Duct Epithelial Cells.
    November 20, 2013
  3. Genotype-Specific Alterations in Vascular Smooth Muscle Cell Function in Cystic Fibrosis Piglets.
    October 21, 2013
  4. Immunohistochemical Expression of MUC5B in Human and Porcine Airways
    October 2013
  5. Mucociliary Transport in Newborn CF and Non-CF Pigs
    October 2013
  6. Reduced PH Increases Viscosity of Porcine Cystic Fibrosis Airway Surface Liquid
    October 2013
  7. Air Trapping and Airflow Obstruction in Newborn Cystic Fibrosis Piglets
    October 2013
  8. Acute Inflammatory Responses to Bacterial Challenge in Newborn CF and Non-CF Pigs
    October 2013
  9. Expression and Localization of Porcine Airway Mucins
    October 2013
  10. Air Trapping Occurs Prior to the Onset of Airway Infection, Inflammation, and Mucus Obstruction in CF Pigs
    October 2013
  11. Abundant DNase I Sensitive Bacterial DNA in Healthy Porcine Lungs: Implications for the Lung Microbiome.
    July 2013
  12. Intestinal CFTR Expression Alleviates Meconium Ileus in Cystic Fibrosis Pigs
    May 2013
  13. Adenoviral Gene Transfer Corrects the Ion Transport Defect in the Sinus Epithelia of a Porcine CF Model.
    March 19, 2013
  14. CFTR-Deficient Pigs Display Peripheral Nervous System Defects at Birth.
    February 4, 2013


  1. Interleukin-13 Induces Comparable Goblet Cell Hyperplasia in Cystic Fibrosis and Non-Cystic Fibrosis Airway Epithelial Cultures
    September 2012
  2. Understanding the CF Airway Surface With the CF Pig
    September 2012
  3. Abnormal Regulation of Airway Smooth Muscle Function in Newborn Cystic Fibrosis Pigs
    September 2012
  4. Sinus Hypoplasia Precedes Sinus Infection in a Porcine Model of Cystic Fibrosis
    September 2012
  5. Computer-Aided Analysis of Airway Trees in Micro-CT Scans of Ex-Vivo Porcine Lung Tissue
    September 2012
  6. Pancreatic and Biliary Secretion Are Both Altered in Cystic Fibrosis Pigs
    August 30, 2012
  7. Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung.
    July 4, 2012
  8. Sinus Hypoplasia Precedes Sinus Infection in a Porcine Model of Cystic Fibrosis.
    September, 2012
  9. Pancreatic Damage in Fetal and Newborn Cystic Fibrosis Pigs Involves the Activation of Inflammatory and Remodeling Pathways.
    June 8, 2012
  10. The Cytokines Interleukin-1β and Tumor Necrosis Factor-α Stimulate CFTR-Mediated Fluid Secretion by Swine Airway Submucosal Glands.
    June 8, 2012
  11. CFTR is Required for Maximal Transepithelial Liquid Transport in Pig Alveolar Epithelia.
    May 25, 2012
  12. Cystic Fibrosis Pigs Have Altered Airway Smooth Muscle Function At Birth
    May 2012
  13. Requirements for Ion and Solute Transport, and pH Regulation During Enamel Maturation.
    April 2012
  14. Chloride Secretion by Cultures of Pig Tracheal Gland Cells.
    February 24, 2012


  1. Properties of Substance P-Stimulated Mucus Secretion From Porcine Tracheal Submucosal Glands.
    December 23, 2011
  2. New Animal Models of Cystic Fibrosis: What Are They Teaching Us?
    November 17, 2011
  3. An Activated Immune and Inflammatory Response Targets the Pancreas of Newborn Pigs With Cystic Fibrosis.
    November 1, 2011
  4. Intestinal Expression of CFTR Alleviates the Meconium Ileus Phenotype in Cystic Fibrosis Pigs
    November 2011
  5. Endogenous Surface Expression of ΔF508-CFTR Mediates cAMP-Stimulated Cl(-) Current in CFTR(ΔF508/ΔF508) Pig Thyroid Epithelial Cells.
    September 23, 2011
  6. Defective Fluid Secretion From Submucosal Glands of Nasal Turbinates From CFTR-/- and CFTR (ΔF508/ΔF508) Pigs.
    August 31, 2011
  7. Human Cystic Fibrosis Airway Epithelia Have Reduced Cl- Conductance But Not Increased Na+ Conductance.
    June 21, 2011
  8. Swine Models of Cystic Fibrosis Reveal Male Reproductive Tract Phenotype at Birth.
    May 18, 2011
  9. Concentration of the Antibacterial Precursor Thiocyanate in Cystic Fibrosis Airway Secretions.
    February 18, 2011
  10. Sinus Disease in CFTR-/- Pigs
    January 2011
  11. Absence of CFTR Disrupts Airway Smooth Muscle Function in a Porcine Model of Cystic Fibrosis
    January 2011
  12. Morphometric Analysis of Exocrine Pig Pancreas Suggets A Sequential Pathogenesis for Fetal CF Pancreas Disease
    January 2011
  13. Production of Antimicrobial Peptides is Preserved in the Airways of Pigs With Cystic Fibrosis
    January 2011
  14. Newborn Cystic Fibrosis Pig Tracheal Lobe Airway Diameter and Compliance Measured With Micro-CT
    January 2011
  15. What Do New Animal Models Teach Us About Lung Infections in CF?
    January 2011
  16. Cystic Fibrosis: An-Ion Transport Issue?
    February 17, 2011
  17. The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs
    March 16, 2011
  18. Enamel Pathology Resulting From Loss of Function in the Cystic Fibrosis Transmembrane Conductance Regulator in a Porcine Animal Model.
    April 28, 2011
  19. Pancreatic and Biliary Secretion Differ in Cystic Fibrosis and Wild-Type Pigs
    June 2011
  20. Efficient Production of Fah-Null Heterozygote Pigs By Chimeric Adeno-Associated Virus-Mediated Gene Knockout and Somatic Cell Nuclear Transfer.
    August 9, 2011


  1. Altered Ion Transport By Thyroid Epithelia From CFTR(-/-) Pigs Suggests Mechanisms For Hypothyroidism in Cystic Fibrosis.
    December 2010
  2. Thyroid Glands From Pigs With Cystic Fibrosis, Old Issues, New Ways.
    December 2010
  3. Loss of Anion Transport Without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia.
    December 10, 2010
  4. Pigs and Humans With Cystic Fibrosis Have Reduced Insulin-Like Growth Factor 1 (IGF1) Levels at Birth.
    November 23, 2010
  5. Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children
    November 2010
  6. Hyposecretion of Fluid From Tracheal Submucosal Glands of CFTR-Deficient Pigs.
    September 2010
  7. Transgenic Animals May Help Resolve a Sticky Situation in Cystic Fibrosis.
    September 2010
  8. cAMP-Activated Ca2+ Signaling is Required for CFTR-Mediated Serous Cell Fluid Secretion in Porcine and Human Airways.
    September 2010
  9. Role of CFTR on Sinus Development and Disease in the CF Pig
    August 2010
  10. Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children.
    July 9, 2010
  11. Transepithelial Electrolyte And Fluid Transport In Type II Alveolar Epithelia In A Porcine Model Of Cystic Fibrosis
    May 2010
  12. Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth.
    April 28, 2010
  13. Pathology of Gastrointestinal Organs in a Porcine Model of Cystic Fibrosis
    March 2010
  14. Investigation of the Craniofacial and Dental Phenotype in the CFTR-Targeted Pig
    January 2010
  15. Pathology of Gastrointestinal Organs in a Porcine Model of Cystic Fibrosis.
    January 28, 2010
  16. Tracheal Abnormalities Are Present in CFTR-/- Neonatal Pigs and Young Children With CF
    January 2010


  1. Transepithelial Electrolyte Transport By Airway Epithelia in a Porcine Model of Cystic Fibrosis
    January 2009
  2. Hyposecretion of Mucus From Airway Submucosal Glands of CF Piglets
    January 2009
  3. Mucus Hyposecretion From Submucosal Glands From Nasal Turbinate of CF Piglets
    January 2009
  4. Development of a Porcine Model of Cystic Fibrosis.
    January 2009


  1. Production of CFTR-Null and CFTR-ΔF508 Heterozygous Pigs by Adeno-Associated Virus - Mediated Gene Targeting and Somatic Cell Nuclear Transfer
    May 2008